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Image Search Results
Journal: Alzheimer's Research & Therapy
Article Title: Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition
doi: 10.1186/s13195-017-0248-8
Figure Lengend Snippet: POC for the effect of MPP on distinction between subjects. a Intergroup differences in the plasma Aβ concentration with or without 4% MPP solution using xMAP technology. MCI+ and ADD+ subjects show significantly decreased levels of MPP-Aβ42 and MPP-Aβ42/40 ratio compared with CN– subjects (** P < 0.01 and *** P < 0.001 respectively; ANOVA followed by Tukey’s multiple comparison test; CN–, n = 20; MCI+, n = 12; ADD+, n = 23; total subjects, n = 55). b Correlation of global PiB deposition (SUVR) and MPP-Aβs. MPP-Aβ42 level (*** P < 0.001, r = –0.47; Pearson’s correlation) and MPP-Aβ42/40 ratio (** P < 0.01, r = –0.39; Pearson’s correlation) are correlated with global PiB deposition (SUVR). Aβ β-amyloid, MPP mixture of protease inhibitors and phosphatase inhibitors, MCI mild cognitive impairment, ADD Alzheimer’s disease dementia, CN cognitively normal, SUVR standard uptake value ratio, PiB Pittsburgh compound B, – or + PiB negativity or positivity
Article Snippet:
Techniques: Clinical Proteomics, Concentration Assay, Comparison
Journal: Alzheimer's Research & Therapy
Article Title: Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition
doi: 10.1186/s13195-017-0248-8
Figure Lengend Snippet: MPP-Aβs reflect the pathological load of Aβ in the brain. a Intergroup differences of MPP-Aβ levels using xMAP technology (* P < 0.05 and ** P < 0.01, unpaired t test; § P < 0.05, §§ P < 0.01, and §§§ P < 0.001, ANOVA followed by Tukey’s multiple comparison test; # P < 0.10, unpaired t test, trend toward significance; CN–, n = 187, CN+, n = 28, MCI–, n = 50, MCI+, n = 29, ADD–, n = 16, ADD+, n = 43; total subjects n = 353). b Correlation of global PiB deposition (SUVR) and MPP-Aβs ( n = 353, *** P < 0.0001; Pearson’s correlation). c , d MPP-Aβ42, MPP-Aβ40, and MPP-Aβ42/40 levels in ND– ( n = 237; CN– and MCI–), ND+ ( n = 57; CN+ and MCI+), PiB– ( n = 253; CN–, MCI–, and ADD–), and PiB+ ( n = 100; CN+, MCI+, and ADD+) (** P < 0.01, and *** P < 0.001, unpaired t test). Aβ β-amyloid, MPP mixture of protease inhibitors and phosphatase inhibitors, MCI mild cognitive impairment, ADD Alzheimer’s disease dementia, CN cognitively normal, SUVR standard uptake value ratio, PiB Pittsburgh compound B, – or + PiB negativity or positivity, ND nondemented
Article Snippet:
Techniques: Comparison